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About David Sinclair
David A. Sinclair, Ph.D., A.O. is one of the world’s most famous and influential scientists. He is a tenured Professor at Harvard Medical School and TIME magazine named him “one of the 100 most influential people in the world” (2014) and among the “Top 50 People in Healthcare” (2018). His newsletter is at www.lifespanbook.com and you can follow him on Twitter @davidasinclair or IG at davidsinclairphd.
David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, The Rich Roll podcast, among others.
After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you’d most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world’s top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide.
In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab’s discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead.
Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing—and what that means for humanity going forward.
He's applied many of his scientific findings to his own life, as have many of his family members, friends, and colleagues. The results— which, it should be noted, are completely anecdotal—are encouraging. He's now 50, and he feels like a kid. His wife and kids will tell you he acts like one, too. The all live in Boston and enjoy hiking, kayaking, and traveling to unique places in the world together.
David and his wife Sandra are committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. These include Vium; Jupiter Orphan Therapeutics; CohBar; Galileo Bioscience; Wellomics; EdenRoc Sciences and its affiliates Arc Bio, Dovetail Genomics, Claret Medical, Revere Biosciences, UpRNA, MetroBiotech, and Liberty Biosecurity; and Life Biosciences and its affiliates Selphagy Therapeutics, Senolytic Therapeutics, Spotlight Therapeutics, Immetas Therapeutics, Lua, Animal Biosciences, Iduna, Continuum Innovation, Prana (now Alterity); and Jumpstart Fertility. He is an inventor on over forty patents, most of which are licensed to industry or have been filed by companies, including a patent application filed by Mayo Clinic and Harvard Medical School and licensed to Elysium Health, of which any proceeds to him are donated to research. He gives lectures at conferences, museums, not-for-profit events, and occasionally at companies, and he sits on the boards of not-for-profit organizations, including the American Federation for Aging Research. He also serves as an adviser to the Lorraine Cross Award. For an updated list of activities, see https://genetics.med.harvard.edu/sinclair/.
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Books By David Sinclair
In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine’s 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer.
For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease – it is inevitable.
But what if everything you think you know about ageing is wrong?
What if ageing is a disease? And that disease is curable.
In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world’s foremost authorities on genetics and ageing, argues just that. He has dedicated his life’s work to chasing more than a longer lifespan – he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick – a circuit designed to halt reproduction in order to repair damage to the genome –has enabled earth’s early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.
But genes aren’t our destiny; we have more control over them than we’ve been taught to believe. We can’t change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes – like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy – can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like – and what will need to change – when we are all living well to 120 or more.
Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. LIFESPAN is destined to be the biggest book on genes, biology, and longevity of this decade.