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Lifespan: Why We Age--And Why We Don't Have to Hardcover – Illustrated, 10 September 2019

4.6 out of 5 stars 6,915 ratings

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Review

"Brilliant and enthralling." --Wall Street Journal


"
Lifespan gives us hope for an extraordinary life. As the brilliant Dr. David Sinclair explains, aging is a disease, and that disease is treatable. This eye-opening book takes you to frontlines of incredible breakthroughs. What could be more valuable than an extended health lifespan? Enjoy this must read masterpiece!"--Peter H. Diamandis, MD, New York Times bestselling author of Abundance and Bold

"
Lifespan is the book we have been waiting for. It transcends everything we know about aging and longevity--a combination of brilliant scientific work, a pioneering mind, and the dream for a longer, healthier and happier life. Lifespan provides a vision for our future and the roadmap on how to get there, merging scientific breakthroughs and simple lifestyle changes to not only help us feel younger, but actually become younger."--Naomi Whittel, New York Times bestselling author of Glow15

"A tour de force. Sinclair's book, and his life's work ranks with humanity's greatest contributions to helping enhance the joy and happiness of life, ranking with the works of Jenner, Pasteur, Salk, Locke, Gandhi, and Edison.
Lifespan is a groundbreaking literary triptych that expertly combines the science of living longer, a practical checklist to unleash our inner potential for healthy longevity, and a brilliant philosophical, policy and ethical synthesis. A masterpiece."--Martine Rothblatt, founder, Chairwoman of the Board, and CEO of United Therapeutics and creator of SiriusXM Satellite Radio

"A visionary book from one of the most masterful longevity scientists of our time.
Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer."--Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure

"An intellectually fascinating book with tantalizing insights on the most important issue about yours and everyone's future."--Andrew Scott, PhD, professor of economics at London Business School and author of The 100-Year Life

"David is a pioneer poised to change how we think about and understand aging."--Stephanie Lederman, CEO of the American Federation for Aging Research (AFAR), New York

"David Sinclair masterfully presents a bold vision of the future in which humanity is able to slow or reverse the aging process and live younger, healthier lives for longer. He engages the reader in a thorough examination of the science and emerging technologies that will enable humanity to achieve this vision."--Victor J. Dzau, MD, president of the US National Academy of Medicine and CEO of Duke University Medical Center

"For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is
the book to read."--Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimer's

"I have had the pleasure of knowing Dr. David Sinclair and following his groundbreaking research into the causes and reversal of aging for many years. In
Lifespan, David takes us on an entertainingly wild ride into both the author's fascinating personal journey of discovery and his seminal research into why we age. But more importantly, he provides us with the everyday tools that we can all use to stop what he now calls 'the disease of aging.'. . . You owe it to yourself and your loved ones to read and follow his advice, as I have for the last 15 years!"--Steven R Gundry, MD, New York Times bestselling author of The Longevity Paradox and medical director of the International Heart and Lung Institute

"I have written about the brilliant work of David Sinclair for over fifteen years and have watched his life's mission of using science to slow the scourge of old age and dying move from the outer edge to more mainstream biology (he's still pushing boundaries!) as his careful work in the lab has steadily shed light on how the mechanisms of aging work in humans and in other organisms. In
Lifespan, the full force of his optimism, humor, and soft-spoken eloquence as a storyteller-scientist come through. I was charmed and delighted by his skill at blending his own life's narrative and others' with clear and levelheaded explanations of some very complex and emerging science. I'm hoping we have David Sinclair with us and doing his science and writing books for another 500 years, give or take a century."--David Ewing Duncan, award-winning journalist, bestselling author, and curator of Arc Fusion

"If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclair's new book
Lifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant."--Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author

"Imagine a world in which we can live long enough to meet not just our grandchildren, but our great-grandchildren. This is Sinclair's vision for the future of humankind, a vision that looks to science, nature, history, and even politics to make the case that it is possible to live well into our hundreds.
Lifespan is boldly leading the way."--Jason Fung, MD, author of The Diabetes Code and The Obesity Code

"In
Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read."--William W. Li, MD, New York Times bestselling author of Eat to Beat Disease

"In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply."--Siddhartha Mukherjee, Pulitzer Prize-winning and #1 New York Times bestselling author

"Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity."--Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet

"Sinclair's dedication to understanding aging on both a microscopic and global scale is bound to shatter centuries of paradigms."-- "Scientific Inquirer"

"Stepping on the moon changed humanity. In
Lifespan, Sinclair takes the ultimate step for humanity that will transform our lives beyond anything we could ever have imagined. If you can put your deepest beliefs aside, this will be the most important book you will ever read. The author is bold, the science is profound, and our future is here."--Henry Markram, PhD, professor at EPFL, Switzerland, director of the Blue Brain Project, and founder of Frontiers open-access journals

"The book, which surpasses everything we know about aging and life extension, has been written with a rich literary material of impressive depth and clarity to offer a deeper understanding of genetics and human longevity research."-- "Wall Street Pit"

"The most important message and priority of our time. For years to come, humanity will reflect on this book with awe and respect. Read it. . . . Your life depends on it."--Marc Hodosh, former owner & co-creator of TEDMED

"There are few books that have ever made me think about science in a fundamentally new way. David Sinclair's book did that for me on aging. This is a book that anyone who ages must read."--Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and co-author of Code of Codes

"This is the most visionary book about aging I have ever read. Seize the day--and seize this book!"--Dean Ornish, MD, founder and president of the Preventative Medicine Research Institute and New York Times bestselling author of UnDo It!

"Throughout the book, the author's enthusiasm jumps off the page."-- "Kirkus Reviews"

"
Lifespan is entertaining and fast-paced--a whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters ('The Demented Pianist', 'A Better Pill to Swallow'), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point."-- "Nature Journal"

"Sinclair's work on slowing the aging process, and even reversing some aspects of it, could lead to the most significant set of medical breakthroughs since the discovery of antibiotics nearly a century ago."-- "Sydney Morning Herald"

About the Author

David Sinclair, PhD, AO, is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as "one of the 100 most influential people in the world" and top fifty most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than thirty-five awards for his research and major scientific breakthroughs. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. To learn more, visit LifespanBook.com and follow him on Twitter @DavidASinclair.

Matthew LaPlante is an associate professor of journalistic writing at Utah State University, where he teaches news reporting and feature writing. A former US Navy intelligence specialist and Middle East war correspondent, he is the author of
Superlative: The Biology of Extremes and the cowriter of multiple other books on the intersection of science and society. He lives in Salt Lake City and skis in Big Cottonwood Canyon. To learn more, visit MDLaPlante.com and follow him on Twitter @MDLaPlante.

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Product details

  • Publisher ‏ : ‎ Atria Books; Illustrated edition (10 September 2019)
  • Language ‏ : ‎ English
  • Hardcover ‏ : ‎ 432 pages
  • ISBN-10 ‏ : ‎ 1501191977
  • ISBN-13 ‏ : ‎ 978-1501191978
  • Dimensions ‏ : ‎ 15.24 x 3.3 x 22.86 cm
  • Customer Reviews:
    4.6 out of 5 stars 6,915 ratings

About the author

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David A. Sinclair, Ph.D., A.O. is one of the world’s most famous and influential scientists. He is a tenured Professor at Harvard Medical School and TIME magazine named him “one of the 100 most influential people in the world” (2014) and among the “Top 50 People in Healthcare” (2018). His newsletter is at www.lifespanbook.com and you can follow him on Twitter @davidasinclair or IG at davidsinclairphd.

David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, The Rich Roll podcast, among others.

After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you’d most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world’s top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide.

In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab’s discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead.

Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing—and what that means for humanity going forward.

He's applied many of his scientific findings to his own life, as have many of his family members, friends, and colleagues. The results— which, it should be noted, are completely anecdotal—are encouraging. He's now 50, and he feels like a kid. His wife and kids will tell you he acts like one, too. The all live in Boston and enjoy hiking, kayaking, and traveling to unique places in the world together.

David and his wife Sandra are committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. These include Vium; Jupiter Orphan Therapeutics; CohBar; Galileo Bioscience; Wellomics; EdenRoc Sciences and its affiliates Arc Bio, Dovetail Genomics, Claret Medical, Revere Biosciences, UpRNA, MetroBiotech, and Liberty Biosecurity; and Life Biosciences and its affiliates Selphagy Therapeutics, Senolytic Therapeutics, Spotlight Therapeutics, Immetas Therapeutics, Lua, Animal Biosciences, Iduna, Continuum Innovation, Prana (now Alterity); and Jumpstart Fertility. He is an inventor on over forty patents, most of which are licensed to industry or have been filed by companies, including a patent application filed by Mayo Clinic and Harvard Medical School and licensed to Elysium Health, of which any proceeds to him are donated to research. He gives lectures at conferences, museums, not-for-profit events, and occasionally at companies, and he sits on the boards of not-for-profit organizations, including the American Federation for Aging Research. He also serves as an adviser to the Lorraine Cross Award. For an updated list of activities, see https://genetics.med.harvard.edu/sinclair/.

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