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Lifespan: Why We Age – and Why We Don’t Have To Kindle Edition
In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine’s 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer.
For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease – it is inevitable.
But what if everything you think you know about ageing is wrong?
What if ageing is a disease? And that disease is curable.
In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world’s foremost authorities on genetics and ageing, argues just that. He has dedicated his life’s work to chasing more than a longer lifespan – he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick – a circuit designed to halt reproduction in order to repair damage to the genome –has enabled earth’s early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.
But genes aren’t our destiny; we have more control over them than we’ve been taught to believe. We can’t change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes – like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy – can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like – and what will need to change – when we are all living well to 120 or more.
Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. LIFESPAN is destined to be the biggest book on genes, biology, and longevity of this decade.
"Lifespan gives us hope for an extraordinary life. As the brilliant Dr. David Sinclair explains, aging is a disease, and that disease is treatable. This eye-opening book takes you to frontlines of incredible breakthroughs. What could be more valuable than an extended health lifespan? Enjoy this must read masterpiece!"--Peter H. Diamandis, MD, New York Times bestselling author of Abundance and Bold
"Lifespan is the book we have been waiting for. It transcends everything we know about aging and longevity--a combination of brilliant scientific work, a pioneering mind, and the dream for a longer, healthier and happier life. Lifespan provides a vision for our future and the roadmap on how to get there, merging scientific breakthroughs and simple lifestyle changes to not only help us feel younger, but actually become younger."--Naomi Whittel, New York Times bestselling author of Glow15
"A tour de force. Sinclair's book, and his life's work ranks with humanity's greatest contributions to helping enhance the joy and happiness of life, ranking with the works of Jenner, Pasteur, Salk, Locke, Gandhi, and Edison. Lifespan is a groundbreaking literary triptych that expertly combines the science of living longer, a practical checklist to unleash our inner potential for healthy longevity, and a brilliant philosophical, policy and ethical synthesis. A masterpiece."--Martine Rothblatt, founder, Chairwoman of the Board, and CEO of United Therapeutics and creator of SiriusXM Satellite Radio
"A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer."--Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure
"An intellectually fascinating book with tantalizing insights on the most important issue about yours and everyone's future."--Andrew Scott, PhD, professor of economics at London Business School and author of The 100-Year Life
"David is a pioneer poised to change how we think about and understand aging."--Stephanie Lederman, CEO of the American Federation for Aging Research (AFAR), New York
"David Sinclair masterfully presents a bold vision of the future in which humanity is able to slow or reverse the aging process and live younger, healthier lives for longer. He engages the reader in a thorough examination of the science and emerging technologies that will enable humanity to achieve this vision."--Victor J. Dzau, MD, president of the US National Academy of Medicine and CEO of Duke University Medical Center
"For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read."--Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimer's
"I have had the pleasure of knowing Dr. David Sinclair and following his groundbreaking research into the causes and reversal of aging for many years. In Lifespan, David takes us on an entertainingly wild ride into both the author's fascinating personal journey of discovery and his seminal research into why we age. But more importantly, he provides us with the everyday tools that we can all use to stop what he now calls 'the disease of aging.'. . . You owe it to yourself and your loved ones to read and follow his advice, as I have for the last 15 years!"--Steven R Gundry, MD, New York Times bestselling author of The Longevity Paradox and medical director of the International Heart and Lung Institute
"I have written about the brilliant work of David Sinclair for over fifteen years and have watched his life's mission of using science to slow the scourge of old age and dying move from the outer edge to more mainstream biology (he's still pushing boundaries!) as his careful work in the lab has steadily shed light on how the mechanisms of aging work in humans and in other organisms. In Lifespan, the full force of his optimism, humor, and soft-spoken eloquence as a storyteller-scientist come through. I was charmed and delighted by his skill at blending his own life's narrative and others' with clear and levelheaded explanations of some very complex and emerging science. I'm hoping we have David Sinclair with us and doing his science and writing books for another 500 years, give or take a century."--David Ewing Duncan, award-winning journalist, bestselling author, and curator of Arc Fusion
"If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclair's new book Lifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant."--Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author
"Imagine a world in which we can live long enough to meet not just our grandchildren, but our great-grandchildren. This is Sinclair's vision for the future of humankind, a vision that looks to science, nature, history, and even politics to make the case that it is possible to live well into our hundreds. Lifespan is boldly leading the way."--Jason Fung, MD, author of The Diabetes Code and The Obesity Code
"In Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read."--William W. Li, MD, New York Times bestselling author of Eat to Beat Disease
"In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply."--Siddhartha Mukherjee, Pulitzer Prize-winning and #1 New York Times bestselling author
"Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity."--Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet
"Sinclair's dedication to understanding aging on both a microscopic and global scale is bound to shatter centuries of paradigms."-- "Scientific Inquirer"
"Stepping on the moon changed humanity. In Lifespan, Sinclair takes the ultimate step for humanity that will transform our lives beyond anything we could ever have imagined. If you can put your deepest beliefs aside, this will be the most important book you will ever read. The author is bold, the science is profound, and our future is here."--Henry Markram, PhD, professor at EPFL, Switzerland, director of the Blue Brain Project, and founder of Frontiers open-access journals
"The book, which surpasses everything we know about aging and life extension, has been written with a rich literary material of impressive depth and clarity to offer a deeper understanding of genetics and human longevity research."-- "Wall Street Pit"
"The most important message and priority of our time. For years to come, humanity will reflect on this book with awe and respect. Read it. . . . Your life depends on it."--Marc Hodosh, former owner & co-creator of TEDMED
"There are few books that have ever made me think about science in a fundamentally new way. David Sinclair's book did that for me on aging. This is a book that anyone who ages must read."--Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and co-author of Code of Codes
"This is the most visionary book about aging I have ever read. Seize the day--and seize this book!"--Dean Ornish, MD, founder and president of the Preventative Medicine Research Institute and New York Times bestselling author of UnDo It!
"Throughout the book, the author's enthusiasm jumps off the page."-- "Kirkus Reviews"
"Lifespan is entertaining and fast-paced--a whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters ('The Demented Pianist', 'A Better Pill to Swallow'), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point."-- "Nature Journal"
"Sinclair's work on slowing the aging process, and even reversing some aspects of it, could lead to the most significant set of medical breakthroughs since the discovery of antibiotics nearly a century ago."-- "Sydney Morning Herald" --This text refers to the hardcover edition.
About the Author
Matthew LaPlante is an associate professor of journalistic writing at Utah State University, where he teaches news reporting and feature writing. A former US Navy intelligence specialist and Middle East war correspondent, he is the author of Superlative: The Biology of Extremes and the cowriter of multiple other books on the intersection of science and society. He lives in Salt Lake City and skis in Big Cottonwood Canyon. To learn more, visit MDLaPlante.com and follow him on Twitter @MDLaPlante. --This text refers to the hardcover edition.
- ASIN : B07NQ2D32G
- Publisher : Thorsons (10 September 2019)
- Language : English
- File size : 25992 KB
- Text-to-Speech : Enabled
- Screen Reader : Supported
- Enhanced typesetting : Enabled
- X-Ray : Enabled
- Word Wise : Enabled
- Print length : 433 pages
- Best Sellers Rank: 9,290 in Kindle Store (See Top 100 in Kindle Store)
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Top reviews from Australia
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Having followed Dr Sinclair's research literally for the last seven months, I can attest that my health and fitness have improved dramatically in that time, and I was a professional athlete who has kept reasonably fit for 67 years old.
Upon reading the research that Dr Sinclair and his colleagues throughout the world have completed, you will understand how simple the ageing process is, yet extremely complicated to research. Most great breakthroughs follow the same guidelines.
Enjoy the read and change your life.
Cancer, Alzheimer's, heart disease, and even COVID-19, are all diseases of which aging plays a fundamental role. As a leader in his field of research, David Sinclair articulates why targeting *biological* aging as a 'disease' should be a priority for medicine in the context of an aging population.
Crucially, aging does not just affect the 'elderly'. So many genetic and environmental factors lead to accelerated aging, including depression, stress, chemotherapy, HIV/AIDS, down syndrome, diabetes etc.; aging affects all of us and occurs at a cellular level throughout life...
If COVID-19 didn't make it obvious enough, it is about time we did something about biological aging.
Must read to all. If you Love someone , please get this book as a gift.
Aging - as cellular damage is also the mechanism behind many "big name" problems like cancer, heart disease, loss of skin plasticity etc. Stopping aging also discourages these conditions for developing in the first place. Interesting read.
Top reviews from other countries
I think a typical scientist would and should stop right there; for science does not concern itself with morality but with pure knowledge whether constructive or destructive. Nonetheless, Dr Sinclair goes on to debate the real and political consequences of people living, if not forever, certainly much longer than they do now. To me, this is where the book rapidly goes down hill. Dr Sinclair knows there will be serious repercussions: an increase in population; a greater demand for resources; more pollution; more carbon emissions; etc, etc. He says that alongside the big increase in population in the 1800's was a huge increase in the standard of sanitation and health as though it were causative - more people lead to more benefits. He thinks that GMO and foods modified by other technologies will provide the solution to feeding the ever-increasing numbers of mouths and gets irritated when some people have the temerity to question their safety. Also, because he would be content to work doing his interesting research in his lab for the next 50 years, it does not mean a miner would like to spend another 50 digging coal.
Despite Dr Sinclair's faith in the ingenuity of man, there are times when i sense he is trying to convince himself of his utopian vision rather than the reader. Living to infinity is not the be all and end all; living a healthy life is more important, whether one lives to 70 or 90.
At some point I will re-read the first half of the book - which I enjoyed - but not the second. I must be only part Luddite.
Richard Dawkins touched on why we would inherit genes that fail as we age: essentially we reproduce before we suffer from these age-related ailments, and so natural selection has not filtered it out as it presumably has young man/woman ailments that would kill off the would-be reproducer.
The book uses scientific terms and explanations and so some reading on physiology may be beneficial alongside this book. Note taking is a must if you're wanting to retain and be able to explain the contents.
The reason I've given it 3 out of 5 stars is the completely lack of concern over the animals the author and his colleagues tested on. I know its commonplace (though this doesn't make it right) but there is not even any acknowledgement from the author that this is cruel behaviour. He will talk about how he'll age mice prematurely (yes fascinating but cruel), starve them, dissect them prior to natural death, etc. He does comment on how easy it is to buy mice to test on, though. Well, as long as subjecting unlucky animals to torture is convenient!